Article

Longitudinal structural variant phylogenies define tumor evolution under therapeutic selection pressure in metastatic prostate cancer

2025-02-03

Abstract excerpt

Therapeutic pressure shapes tumor evolution by selecting for subclones with distinct genomic architectures. In metastatic castration-resistant prostate cancer (mCRPC), structural variants (SVs) are central to this process but rarely incorporated into clonal reconstruction from bulk DNA sequencing. We describe SVCFit, a computational framework that estimates the cellular fraction of diverse SV classes from whole-ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5dcdf613-2c85-5d95-a45b-185869bc85f4
DOI: 10.1101/2025.02.01.636056

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Longitudinal structural variant phylogenies define tumor evolution under therapeutic selection pressure in metastatic prostate cancerDOI 10.1101/2025.02.01.636056Read

Longitudinal Profiling of Circulating Tumor DNA Reveals the Evolutionary Dynamics of Metastatic Prostate Cancer during Serial TherapySemantic proximity Read

DeCiFering the elusive cancer cell fraction in tumor heterogeneity and evolution.Semantic proximity Read

Quantifying the influence of mutation detection on tumour subclonal reconstruction.Semantic proximity Read

Quantifying the Influence of Mutation Detection on Tumour Subclonal ReconstructionSemantic proximity Read

Unraveling the clonal hierarchy of somatic genomic aberrations.Semantic proximity Read

Inferring structural variant cancer cell fractionSemantic proximity Read

Reconstructing tumor clonal heterogeneity and evolutionary relationships based on tumor DNA sequencing data.Semantic proximity Read

Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing.Semantic proximity Read

Single-cell genomic analysis of cancer cells from one treatment-naïve patient with metastatic prostate cancer.Semantic proximity Read

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.Semantic proximity Read

Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis.Semantic proximity Read

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of cancerSemantic proximity Read