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Article

Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype.

Scientific reports - 19 Feb 2020

Friedberg Jacob S, Aytan Nurgul, Cherry Jonathan D, Xia Weiming, Standring Oliver J, Alvarez Victor E, Nicks Raymond, Svirsky Sarah, Meng Gaoyuan, Jun Gyungah, Ryu Hoon, Au Rhoda, Stein Thor D

Abstract excerpt

Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε4 allele is the most common genetic risk factor for AD and is related to a pro-inflammatory state. To test the hypothesis that microglia and AD-implicated cytokines were differentially associated with AD pathology based on the...

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Identifiers

PMID: 32076055
DOI: 10.1038/s41598-020-59869-5
PMCID: PMC7031423

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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