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Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

12 Aug 2021

Abstract excerpt

Neuroendocrine prostate cancer is an aggressive variant of prostate cancer that may arise de novo or develop from pre-existing prostate adenocarcinoma as a mechanism of treatment resistance. The combined loss of tumor suppressors RB1, TP53, and PTEN are frequent in NEPC but also present in a subset of prostate adenocarcinomas. Most clinical and preclinical studies support a trans-differentiation process, whereby...

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PMID: 34385567
DOI: 10.1038/s41698-021-00211-1

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