Article

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

2020-09-14

Abstract excerpt

Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong histological and clinical similarities. Here we report the chromatin landscapes of a range of human NECs and show convergence to the activation of a common epigenetic program. With a particular focus on treatment emergent neuroendocrine prostate cancer (NEPC), we anal...

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Literature Corpus work: 4bea87fe-e8ef-55de-a133-5fd6b236d7b7
DOI: 10.1101/2020.09.13.291328

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