Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

1 Oct 2021

Abstract excerpt

Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong histological and clinical similarities. Here we report the chromatin landscapes of a range of human NECs and show convergence to the activation of a common epigenetic program. With a particular focus on treatment emergent neuroendocrine prostate cancer (NEPC), we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34599169
DOI: 10.1038/s41467-021-26042-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancerPMID 34599169Read ↗

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate CancerSemantic proximity Read ↗

Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptorsSemantic proximity Read ↗

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancerSemantic proximity Read ↗

Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancerSemantic proximity Read ↗

The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications.Semantic proximity Read ↗

Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancerSemantic proximity Read ↗

Treatment-related Neuroendocrine Prostate Carcinoma—Diagnostic and Molecular CorrelatesSemantic proximity Read ↗

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancerSemantic proximity Read ↗

The epigenetic and transcriptional landscape of neuroendocrine prostate cancerSemantic proximity Read ↗

Neuroendocrine Prostate Cancer: Subtypes, Biology, and Clinical OutcomesSemantic proximity Read ↗

Therapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.