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Article

Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer

23 Feb 2020

Abstract excerpt

Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%-20% of advanced treatment-resistant prostate cancers, and this may manifest clinically as transformation from a prostate adenocarcinoma histology to a castration-resistant neuroendocrine prostate cancer (CRPC-NE). The diagnosis of CRPC-NE currently relies on a metastatic tumor biopsy, which is invasive for patients and sometimes...

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PMID: 32091413
DOI: 10.1172/jci131041

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