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Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer

13 Jun 2022

Abstract excerpt

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. However, little is known about its origin and the mechanisms governing its emergence. Our study characterized ADPC and NEPC in prostate tumors from 7 patients using scRNA-seq. First, we identified two NEPC gene expression signatures representing different phases of trans -differentiation. New marker...

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PMID: 35789834
DOI: 10.1016/j.isci.2022.104576

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