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Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer case

21 Jun 2022

Abstract excerpt

Little is known about the complexity and plasticity of circulating tumor cell (CTC) biology in different compartments of the fluid microenvironment during tumor metastasis. Here we integrated phenomics, genomics, and targeted proteomics to characterize CTC phenotypic and genotypic heterogeneity in paired peripheral blood (PB) and bone marrow aspirate (BMA) from a metastatic prostate cancer patient following the...

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PMID: 35729213
DOI: 10.1038/s41698-022-00289-1

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