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Article

A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2021

Haubrich Jordi, Font Joan, Quast Robert B, Goupil-Lamy Anne, Scholler Pauline, Nevoltris Damien, Acher Francine, Chames Patrick, Rondard Philippe, Prézeau Laurent, Pin Jean-Philippe

Abstract excerpt

There is growing interest in developing biologics due to their high target selectivity. The G protein-coupled homo- and heterodimeric metabotropic glutamate (mGlu) receptors regulate many synapses and are promising targets for the treatment of numerous brain diseases. Although subtype-selective allosteric small molecules have been reported, their effects on the recently discovered heterodimeric receptors are...

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Identifiers

PMID: 34385321
DOI: 10.1073/pnas.2105848118
PMCID: PMC8379968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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