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Article

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.

Molecular pharmacology - 1 May 2016

Stroebel David, Buhl Derek L, Knafels John D, Chanda Pranab K, Green Michael, Sciabola Simone, Mony Laetitia, Paoletti Pierre, Pandit Jayvardhan

Abstract excerpt

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key roles in brain physiology and pathology. Because numerous pathologic conditions involve NMDAR overactivation, subunit-selective antagonists hold strong therapeutic potential, although clinical successes remain limited. Among the most promising NMDAR-targeting drugs are allosteric inhibitors of GluN2B-containing receptors. Since...

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Identifiers

PMID: 26912815
DOI: 10.1124/mol.115.103036
PMCID: PMC4859819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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