Article

Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activation

2022-01-08

Abstract excerpt

Selective allosteric modulators bear great potential to fine-tune neurotransmitter-induced brain receptor responses. Promising targets are metabotropic glutamate (mGlu) receptors, which are associated to different brain diseases. These multidomain class C GPCRs experience concerted structural rearrangements and rely on allosteric modulation of agonist action to be fully activated. Here we establish live cell compa...

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Literature Corpus work: 0b83d7bd-6bd2-583f-8fe7-3aa8314e1864
DOI: 10.1101/2022.01.07.474531

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