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Article

Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.

Structure (London, England : 1993) - 5 Jul 2017

Pérez-Benito Laura, Doornbos Maarten L J, Cordomí Arnau, Peeters Luc, Lavreysen Hilde, Pardo Leonardo, Tresadern Gary

Abstract excerpt

Metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) crucial for CNS function and important drug discovery targets. Glutamate triggers receptor activation from an extracellular domain binding site while allosteric modulators bind in the seven-transmembrane domain. Little is known about how allosteric modulators produce their functional effects at the molecular level. Here we...

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Identifiers

PMID: 28648611
DOI: 10.1016/j.str.2017.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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