Article

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

2023-01-03

Abstract excerpt

The α7 nicotinic acetylcholine receptor (nAChR), a potential drug target for treating cognitive disorders, mediates communication between neuronal and non-neuronal cells. Although many competitive antagonists, agonists, and partial-agonists have been found and synthesized, they have not led to effective therapeutic treatments. In this context, small molecules acting as positive allosteric modulators binding outsid...

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Literature Corpus work: 3f89aecf-514e-5ff3-a3bc-25b359a22b83
DOI: 10.1101/2023.01.03.522562

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