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Article

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.

Scientific reports - 11 Sept 2015

Harpsøe Kasper, Isberg Vignir, Tehan Benjamin G, Weiss Dahlia, Arsova Angela, Marshall Fiona H, Bräuner-Osborne Hans, Gloriam David E

Abstract excerpt

The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. They are among the most highly pursued drug targets, with relevance for several neurological diseases, and a number of allosteric modulators have entered clinical trials. However, so far this has not led to a marketed drug, largely because of the difficulties in achieving subtype-selective compounds with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26359761
DOI: 10.1038/srep13869
PMCID: PMC4566082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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