Article
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
eLife - 21 Apr 2021
Thibado Jordana K, Tano Jean-Yves, Lee Joon, Salas-Estrada Leslie, Provasi Davide, Strauss Alexa, Marcelo Lamim Ribeiro Joao, Xiang Guoqing, Broichhagen Johannes, Filizola Marta, Lohse Martin J, Levitz Joshua
Abstract excerpt
The metabotropic glutamate receptors (mGluRs) form a family of neuromodulatory G-protein-coupled receptors that contain both a seven-helix transmembrane domain (TMD) and a large extracellular ligand-binding domain (LBD) which enables stable dimerization. Although numerous studies have revealed variability across subtypes in the initial activation steps at the level of LBD dimers, an understanding of inter-TMD...
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