Article

An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodies

2023-01-03

Abstract excerpt

The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest to design ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7 ligands, we recently generated two nanobodies named E3 and C4 acting as positive and silent allosteric modulators respectively. Here, we solved the cryo-EM structure...

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Literature Corpus work: f2e64591-38f9-554a-9b14-74d39b715b9d
DOI: 10.1101/2023.01.03.522595

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An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodiesDOI 10.1101/2023.01.03.522595Read

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