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Article

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.

British journal of pharmacology - 1 May 2015

Farinha A, Lavreysen H, Peeters L, Russo B, Masure S, Trabanco A A, Cid J, Tresadern G

Abstract excerpt

BACKGROUND AND PURPOSE: The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tuned potentiation of these receptors' function and are being investigated as a novel therapeutic approach. An extensive...

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Identifiers

PMID: 25571949
DOI: 10.1111/bph.13065
PMCID: PMC4403101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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