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Article

Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs.

Scientific reports - 13 Mar 2018

Nasrallah Chady, Rottier Karine, Marcellin Romain, Compan Vincent, Font Joan, Llebaria Amadeu, Pin Jean-Philippe, Banères Jean-Louis, Lebon Guillaume

Abstract excerpt

The metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) that modulate synaptic activity and plasticity throughout the mammalian brain. Signal transduction is initiated by glutamate binding to the venus flytrap domains (VFT), which initiates a conformational change that is transmitted to the conserved heptahelical domains (7TM) and results ultimately in the activation of...

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Share to GTP-Binding Protein alpha Subunits, Gq-G11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29535347
DOI: 10.1038/s41598-018-22729-4
PMCID: PMC5849714

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PAM

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