Article

Pharmacological characterisation of allosteric modulators at human mGlu <sub>5</sub>

2024-12-06

Abstract excerpt

The metabotropic glutamate receptor 5 (mGlu 5 ) is a Class C G protein-coupled receptor, ubiquitously expressed throughout the CNS. With major roles in cognition, learning and memory, mGlu 5 dysfunction is linked with numerous neurodegenerative and neuropsychiatric disorders, presenting a viable therapeutic target. Allosteric modulators bind topographically distinct sites from glutamate and other orthosteric ago...

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Literature Corpus work: c658b10a-8176-520e-b63e-7b357724a39b
DOI: 10.1101/2024.12.05.627101

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