Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the Protein-Metabolite Interplay to Discover Novel Drug Targets for Alzheimer's Disease.

The journal of gene medicine - 1 Sept 2025

Yin Kang-Fu, Gu Xiao-Jing, Jiang Zheng, Su Wei-Ming, Duan Qing-Qing, He Sheng-Yi, Cao Bei, Chen Qin, Zhang Qin, Chen Yong-Ping

Abstract excerpt

BACKGROUND: The protein-metabolite interactions play a pivotal role in the pathogenesis of Alzheimer's disease (AD); however, the causal significance of these interactions in AD pathogenesis remains elusive. METHODS: We integrated datasets of protein quantitative trait loci (pQTL), metabolite quantitative trait loci (mQTL), and genome-wide association study (GWAS) for AD. Initially, we performed MR analysis to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolome

Share to Metabolomics

Share to Protein Interaction Maps

Share to Proteomics

Share to Quantitative Trait Loci

Share to Receptors, Immunologic

Source

Identifiers

PMID: 40974265
DOI: 10.1002/jgm.70035

Genes

BIN1
C1R
LILRB1
TMEM106B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the Protein-Metabolite Interplay to Discover Novel Drug Targets for Alzheimer's Disease.PMID 40974265Read ↗

Multi-Omics Integration Analysis Pinpoint Proteins Influencing Brain Structure and Function: Toward Drug Targets and Neuroimaging Biomarkers for Neuropsychiatric Disorders.Semantic proximity Read ↗

Identification of novel drug targets for Alzheimer's disease by integrating genetics and proteomes from brain and blood.Semantic proximity Read ↗

An Integrated Molecular Atlas of Alzheimer’s DiseaseSemantic proximity Read ↗

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for drug discoverySemantic proximity Read ↗

Assessing Causal Relationship Between Human Blood Metabolites and Five Neurodegenerative Diseases With GWAS Summary StatisticsSemantic proximity Read ↗

Proteome-wide association study identifies novel Alzheimer's disease- associated proteinsSemantic proximity Read ↗

Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data.Semantic proximity Read ↗

Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s diseaseSemantic proximity Read ↗

Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participantsSemantic proximity Read ↗

Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study.Semantic proximity Read ↗

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis.Semantic proximity Read ↗

A review and analysis of key biomarkers in Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.