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Article

Type F mutation of nucleophosmin 1 Acute Myeloid Leukemia: A tale of disorder and aggregation.

International journal of biological macromolecules - 1 Oct 2021

La Manna Sara, Florio Daniele, Di Natale Concetta, Scognamiglio Pasqualina Liana, Sibillano Teresa, Netti Paolo A, Giannini Cinzia, Marasco Daniela

Abstract excerpt

Protein aggregation is suggested as a reversible, wide-spread physiological process used by cells to regulate their growth and adapt to different stress conditions. Nucleophosmin 1(NPM1) protein is an abundant multifunctional nucleolar chaperone and its gene is the most frequently mutated in Acute Myeloid Leukemia (AML) patients. So far, the role of NPM1 mutations in leukemogenesis has remained largely elusive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34364939
DOI: 10.1016/j.ijbiomac.2021.08.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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