Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleophosmin 1 Mutations in Acute Myeloid Leukemia.

Genes - 12 Jun 2020

Zarka Jabra, Short Nicholas J, Kanagal-Shamanna Rashmi, Issa Ghayas C

Abstract excerpt

Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein involved in ribosome biogenesis, the maintenance of genomic integrity and the regulation of the ARF-p53 tumor-suppressor pathway among multiple other functions. Mutations in the corresponding gene cause a cytoplasmic dislocation of the NPM1 protein. These mutations are unique to acute myeloid leukemia (AML), a disease characterized by clonal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factor 1
Share to Cytoplasm
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 32545659
DOI: 10.3390/genes11060649
PMCID: PMC7348733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleophosmin 1 Mutations in Acute Myeloid Leukemia.PMID 32545659Read ↗

Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features.Semantic proximity Read ↗

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia.Semantic proximity Read ↗

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemiaSemantic proximity Read ↗

Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives.Semantic proximity Read ↗

Nucleophosmin gene mutations in acute myeloid leukemia.Semantic proximity Read ↗

Role of nucleophosmin in acute myeloid leukemia.Semantic proximity Read ↗

Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Semantic proximity Read ↗

Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.Semantic proximity Read ↗

When the good go bad: Mutant NPM1 in acute myeloid leukemia.Semantic proximity Read ↗

Recent advances in AML with mutated NPM1.Semantic proximity Read ↗

Significance of NPM1 Gene Mutations in AML.Semantic proximity Read ↗

Functions of the native NPM1 protein and its leukemic mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.