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Article

Type C mutation of nucleophosmin 1 acute myeloid leukemia: Consequences of intrinsic disorder.

Biochimica et biophysica acta. General subjects - 1 Aug 2022

La Manna Sara, Florio Daniele, Di Natale Concetta, Lagreca Elena, Sibillano Teresa, Giannini Cinzia, Marasco Daniela

Abstract excerpt

BACKGROUND: Nucleophosmin 1 (NPM1) protein is a multifunctional nucleolar chaperone and its gene is the most frequently mutated in Acute Myeloid Leukemia (AML). AML mutations cause the unfolding of the C-terminal domain (CTD) and the protein delocalizing in the cytosol (NPM1c+). Marked aggregation endowed with an amyloid character was assessed as consequences of mutations. SCOPE: Herein we analyzed the effects of...

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Identifiers

PMID: 35597503
DOI: 10.1016/j.bbagen.2022.130173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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