Article
Small molecules enhancers of amyloid aggregation of C-terminal domain of Nucleophosmin 1 in acute myeloid leukemia.
Bioorganic chemistry - 1 Oct 2022
Florio Daniele, Roviello Valentina, La Manna Sara, Napolitano Fabiana, Maria Malfitano Anna, Marasco Daniela
Abstract excerpt
The "Acute Myeloid Leukemia with gene mutations'' group includes mutations in Nucleophosmin 1(NPM1) that is an abundant multifunctional protein with chaperon functions. This protein also takes part to rRNA maturation in ribosome biogenesis, tumor suppression and nucleolar stress response. Mutations of NPM1 associated to AML present in its C-terminal domain (CTD) unable its correct folding and confer it an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.