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Article

Insights into Network of Hot Spots of Aggregation in Nucleophosmin 1.

International journal of molecular sciences - 25 Nov 2022

Florio Daniele, La Manna Sara, Di Natale Concetta, Leone Marilisa, Mercurio Flavia Anna, Napolitano Fabiana, Malfitano Anna Maria, Marasco Daniela

Abstract excerpt

In a protein, point mutations associated with diseases can alter the native structure and provide loss or alteration of functional levels, and an internal structural network defines the connectivity among domains, as well as aggregate/soluble states' equilibria. Nucleophosmin (NPM)1 is an abundant nucleolar protein, which becomes mutated in acute myeloid leukemia (AML) patients. NPM1-dependent leukemogenesis,...

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Identifiers

PMID: 36499032
DOI: 10.3390/ijms232314704
PMCID: PMC9736328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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