Article
Conformational consequences of NPM1 rare mutations: An aggregation perspective in Acute Myeloid Leukemia.
Bioorganic chemistry - 1 Aug 2021
La Manna Sara, Florio Daniele, Di Natale Concetta, Napolitano Fabiana, Malfitano Anna Maria, Netti Paolo A, De Benedictis Ilaria, Marasco Daniela
Abstract excerpt
Often proteins association is a physiological process used by cells to regulate their growth and to adapt to different stress conditions, including mutations. In the case of a subtype of Acute Myeloid Leukemia (AML), mutations of nucleophosmin 1 (NPM1) protein cause its aberrant cytoplasmatic mislocalization (NPMc+). We recently pointed out an amyloidogenic propensity of protein regions including the most common...
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