Functions of the native NPM1 protein and its leukemic mutant.

Abstract excerpt

The nucleophosmin (NPM1) gene encodes for the most abundant nucleolar protein. Thanks to its property to act as histone chaperone and to shuttle between the nucleus and cytoplasm, the NPM1 protein is involved in multiple cellular function that are here extensively reviewed and include the formation of the nucleolus through liquid-liquid phase separation, regulation of ribosome biogenesis and transport, control of...

Topics

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• Mutation
• Cell Nucleolus
• NPM1 gene
• Leukemia, Myeloid, Acute
• Mice
• Nuclear Proteins