Article
Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.
Protein science : a publication of the Protein Society - 1 May 2013
Federici Luca, Falini Brunangelo
Abstract excerpt
Nucleophosmin (NPM1) is an abundant, ubiquitously expressed protein mainly localized at nucleoli but continuously shuttling between nucleus and cytoplasm. NPM1 plays a role in several cellular functions, including ribosome biogenesis and export, centrosome duplication, chromatin remodeling, DNA repair, and response to stress stimuli. Much of the interest in this protein arises from its relevance in human...
Topics
- Active Transport, Cell Nucleus
- Amino Acid Sequence
- Animals
- G-Quadruplexes
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Myeloid, Acute
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nuclear Proteins