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Article

Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features.

Cancer treatment and research - 1 Jan 2010

Falini Brunangelo

Abstract excerpt

The NPM1 gene encodes for nucleophosmin, a nucleolus-located shuttling protein that is involved in multiple cell functions, including regulation of ribosome biogenesis, control of centrosome duplication and preservation of ARF tumor suppressor integrity. The NPM1 gene is specifically mutated in about 30% acute myeloid leukemia (AML) but not in other human neoplasms. Mutations cause crucial changes at the...

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Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

Share to Protein Transport

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Source

Identifiers

PMID: 20306250
DOI: 10.1007/978-0-387-69259-3_9

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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