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Article

Proteostasis unbalance of nucleophosmin 1 in Acute Myeloid Leukemia: An aggregomic perspective.

International journal of biological macromolecules - 1 Dec 2020

Di Natale Concetta, Florio Daniele, Di Somma Sarah, Di Matteo Adele, Federici Luca, Netti Paolo Antonio, Morelli Giancarlo, Malfitano Anna Maria, Marasco Daniela

Abstract excerpt

The role exerted by the nucleus in the regulation of proteostasis in both health and disease is recognized of outmost importance, even though not fully understood. Many recent investigations are focused on its ability to modulate and coordinate protein quality control machineries in mammalian cells. Nucleophosmin 1 (NPM1) is one of the most abundant nucleolar proteins and its gene is mutated in ~30% of Acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32890557
DOI: 10.1016/j.ijbiomac.2020.08.248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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