Article
Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.
Oncotarget - 27 Sept 2016
Lindqvist C Mårten, Lundmark Anders, Nordlund Jessica, Freyhult Eva, Ekman Diana, Carlsson Almlöf Jonas, Raine Amanda, Övernäs Elin, Abrahamsson Jonas, Frost Britt-Marie, Grandér Dan, Heyman Mats, Palle Josefine, Forestier Erik, Lönnerholm Gudmar, Berglund Eva C, Syvänen Ann-Christine
Abstract excerpt
To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL patients. We found an overall greater mutational burden and more driver mutations in T-cell ALL (T-ALL) patients compared to B-cell precursor ALL (BCP-ALL) patients. In addition, the majority of the mutations...
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