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Article

Augmenting and directing long-range CRISPR-mediated activation in human cells.

Nature methods - 1 Sept 2021

Tak Y Esther, Horng Joy E, Perry Nicholas T, Schultz Hayley T, Iyer Sowmya, Yao Qiuming, Zou Luli S, Aryee Martin J, Pinello Luca, Joung J Keith

Abstract excerpt

Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although human genes can be robustly upregulated by targeting aTFs to promoters, the activation induced by directing aTFs to distal transcriptional enhancers is substantially less robust and consistent. Here we show that long-range activation using CRISPR-based aTFs in human...

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Identifiers

PMID: 34354266
DOI: 10.1038/s41592-021-01224-1
PMCID: PMC8446310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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