Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins

Abstract excerpt

Programmable epigenome editors modify gene expression in mammalian cells by altering the local chromatin environment at target loci without inducing DNA breaks. However, the large size of CRISPR-based epigenome editors poses a challenge to their broad use in biomedical research and as future therapies. Here, we present Robust ENveloped Delivery of Epigenome-editor Ribonucleoproteins (RENDER) for transiently delive...

Topics

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• Cell Differentiation
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Epigenesis, Genetic
• Gene Editing
• HIV Research and Treatment
• Mosquito-borne diseases and control
• Phenotype

Identifiers and source

Literature Corpus work

b5fc582e-4740-5482-ae87-bcca203bab4c

DOI

10.1101/2024.11.26.625496