Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular Programming

1 Jan 2020

Abstract excerpt

Pinpoint control over endogenous gene expression in vivo has long been a fevered dream for clinicians and researchers alike. With the recent repurposing of programmable, RNA-guided DNA endonucleases from the CRISPR bacterial immune system, this dream is becoming a powerful reality. Engineered CRISPR/Cas9-based transcriptional regulators and epigenome editors have enabled researchers to perturb endogenous gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31972154
DOI: 10.1016/j.cels.2019.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular ProgrammingPMID 31972154Read ↗

Genetic and epigenetic control of gene expression by CRISPR–Cas systemsSemantic proximity Read ↗

CRISPRoff epigenetic editing for programmable gene silencing in human cells without DNA breaksSemantic proximity Read ↗

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian CellsSemantic proximity Read ↗

A synthetic transcription platform for programmable gene expression in mammalian cellsSemantic proximity Read ↗

Next stop for the CRISPR revolution: RNA-guided epigenetic regulators.Semantic proximity Read ↗

Cas9 gRNA engineering for genome editing, activation and repression.Semantic proximity Read ↗

An integrated RNA and CRISPR/Cas toolkit for multiplexed synthetic circuits and endogenous gene regulation in human cellsSemantic proximity Read ↗

Rational design of a compact CRISPR-Cas9 activator for AAV-mediated deliverySemantic proximity Read ↗

Augmenting and directing long-range CRISPR-mediated activation in human cells.Semantic proximity Read ↗

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbationSemantic proximity Read ↗

The Interface of Gene Editing with Regenerative MedicineSemantic proximity Read ↗

Small-molecule inducible transcriptional control in mammalian cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.