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Article

Genetic Risk for Overall Cancer and the Benefit of Adherence to a Healthy Lifestyle.

Cancer research - 1 Sept 2021

Zhu Meng, Wang Tianpei, Huang Yanqian, Zhao Xiaoyu, Ding Yuqing, Zhu Mengyi, Ji Mengmeng, Wang Cheng, Dai Juncheng, Yin Rong, Xu Lin, Ma Hongxia, Wei Qingyi, Jin Guangfu, Hu Zhibin, Shen Hongbing

Abstract excerpt

Cancer site-specific polygenic risk scores (PRS) effectively identify individuals at high risk of individual cancers, but the effectiveness of PRS on overall cancer risk assessment and the extent to which a high genetic risk of overall cancer can be offset by a healthy lifestyle remain unclear. Here, we constructed an incidence-weighted overall cancer polygenic risk score (CPRS) based on 20 cancer site-specific...

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PMID: 34321244
DOI: 10.1158/0008-5472.CAN-21-0836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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