Polygenic Risk Score, Healthy Lifestyle Score, and Colorectal Cancer Risk: A Prospective Cohort Study.

doi:10.1158/1055-9965.EPI-24-1013

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Polygenic Risk Score, Healthy Lifestyle Score, and Colorectal Cancer Risk: A Prospective Cohort Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 6 Feb 2025

Shen Yuefan, Chen Weiwei, Fu Chengqu, Liu Xinyi, Miao Junyan, Li Jiacong, Li Ni, Hang Dong

Abstract excerpt

BACKGROUND: Both genetic factors and lifestyle play a critical role in colorectal cancer, but the extent to which an increased genetic risk can be offset by a healthy lifestyle remains unclear. METHODS: We included 51,171 participants from the Prostate, Lung, Colorectal, and Ovarian Cancer cohort. A polygenic risk score was created based on 205 genetic variants associated with colorectal cancer, and a healthy...

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Topics

Humans
Colorectal Neoplasms
Female
Male
Prospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Healthy Lifestyle

Risk Factors

Aged

Genetic Predisposition to Disease

Multifactorial Inheritance

Genetic Risk Score

Source

Open in PubMed

Identifiers

PMID: 39570087
DOI: 10.1158/1055-9965.EPI-24-1013

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