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Article

Genetic risk, health-associated lifestyle, and risk of early-onset total cancer and breast cancer.

Journal of the National Cancer Institute - 1 Jan 2025

Zhang Yin, Lindström Sara, Kraft Peter, Liu Yuxi

Abstract excerpt

BACKGROUND: Early-onset cancer (diagnosed under age 50) generally manifests as an aggressive disease phenotype. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants remains unclear. METHODS: We analyzed a prospective cohort of 66 308 participants who were under age 50 and free of cancer at baseline in the UK Biobank. Using Cox regression, we estimated...

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Identifiers

PMID: 39189966
DOI: 10.1093/jnci/djae208
PMCID: PMC11717420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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