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Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study.

International journal of cancer - 1 Feb 2025

Ji Chen, Ge Wenjing, Zhu Chen, Shen Fang, Yu Yuhui, Pang Guanlian, Li Qiao, Zhu Mingxuan, Ma Zhimin, Zhu Xia, Fu Yating, Gong Linnan, Wang Tianpei, Du Lingbin, Jin Guangfu, Zhu Meng

Abstract excerpt

Family history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow-up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data (N = 442,399), we constructed PRS and incidence-weighted overall cancer...

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PMID: 39291673
DOI: 10.1002/ijc.35187

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