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Article

Transcription factor Sp1 dysregulation in Alzheimer's disease

30 Apr 2008

Abstract excerpt

Altered gene expression occurs in central nervous system disorders, including Alzheimer's disease (AD). Transcription factor Sp1 may be involved insofar as it can regulate the expression of several AD-related proteins, including amyloid precursor protein (APP) and tau. Sp1 could itself be regulated by inflammatory and other factors associated with AD, such as interleukin-1beta. We measured an almost threefold...

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PMID: 18449948
DOI: 10.1002/jnr.21695

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