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Article

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization.

Nature communications - 16 Jul 2021

Montavon Thomas, Shukeir Nicholas, Erikson Galina, Engist Bettina, Onishi-Seebacher Megumi, Ryan Devon, Musa Yaarub, Mittler Gerhard, Meyer Alexandra Graff, Genoud Christel, Jenuwein Thomas

Abstract excerpt

Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes: Suv39h1/Suv39h2, Eset1/Eset2 and G9a/Glp. We used mouse embryonic fibroblasts (MEFs) with a conditional mutation for Eset1 and introduced progressive deletions for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34272378
DOI: 10.1038/s41467-021-24532-8
PMCID: PMC8285382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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