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Article

Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.

Cell - 31 Aug 2012

Towbin Benjamin D, González-Aguilera Cristina, Sack Ragna, Gaidatzis Dimos, Kalck Véronique, Meister Peter, Askjaer Peter, Gasser Susan M

Abstract excerpt

The factors that sequester transcriptionally repressed heterochromatin at the nuclear periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of S-adenosylmethionine (SAM) synthetase reduces histone methylation globally and causes derepression and release of heterochromatin from the nuclear periphery in Caenorhabditis elegans embryos. Analysis of histone methyltransferases (HMTs)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22939621
DOI: 10.1016/j.cell.2012.06.051

Genes

SET
MET
SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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