Article

ERH elicits cell lineage restriction in mammalian preimplantation development and differentiation from pluripotency via H3K9me3-heterochromatin

2024-06-06

Abstract excerpt

Enhancer of Rudimentary Homolog (ERH) is an evolutionarily conserved protein originally characterized as promoting fission yeast heterochromatin 1 and recently shown to maintain H3K9me3 heterochromatin in human fibroblasts 2 . Here, we find that ERH depletion in fibroblasts reverts the somatic cell H3K9me3 landscape of broad megabase size domains to an embryonic stem cell (ESC) state composed of mainly H3K9me3 p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88bfed3e-9ff9-57fd-98fc-473dc18243a3
DOI: 10.1101/2024.06.06.597604

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ERH elicits cell lineage restriction in mammalian preimplantation development and differentiation from pluripotency via H3K9me3-heterochromatinDOI 10.1101/2024.06.06.597604Read

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cellsSemantic proximity Read

MAPK/ERK signaling blocks ectopic H3K9me3 heterochromatin formation to confer mesoderm and endoderm developmental competenceSemantic proximity Read

Discovery of Competent Chromatin Regions in Human Embryonic Stem CellsSemantic proximity Read

Histone H3-K9 methyltransferase ESET is essential for early development.Semantic proximity Read

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.Semantic proximity Read

Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotencySemantic proximity Read

<i>Eed</i> controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crestSemantic proximity Read

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.Semantic proximity Read

Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identitySemantic proximity Read

Contiguous Erosion of the Inactive X in Human Pluripotency Concludes With Global DNA HypomethylationSemantic proximity Read

H3K36 Methylation - a Guardian of Epigenome IntegritySemantic proximity Read

Epigenetic regulation of early human embryo developmentSemantic proximity Read