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Article

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection.

eLife - 15 Jul 2021

Shipley Mackenzie M, Mangala Prasad Vidya, Doepker Laura E, Dingens Adam, Ralph Duncan K, Harkins Elias, Dhar Amrit, Arenz Dana, Chohan Vrasha, Weight Haidyn, Mandaliya Kishor, Bloom Jesse D, Matsen Frederick A, Lee Kelly K, Overbaugh Julie M

Abstract excerpt

Stimulating broadly neutralizing antibodies (bnAbs) directly from germline remains a barrier for HIV vaccines. HIV superinfection elicits bnAbs more frequently than single infection, providing clues of how to elicit such responses. We used longitudinal antibody sequencing and structural studies to characterize bnAb development from a superinfection case. BnAb QA013.2 bound initial and superinfecting viral Env,...

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Identifiers

PMID: 34263727
DOI: 10.7554/eLife.68110
PMCID: PMC8376252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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