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Article

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies.

Nature medicine - 1 Nov 2015

Bhiman Jinal N, Anthony Colin, Doria-Rose Nicole A, Karimanzira Owen, Schramm Chaim A, Khoza Thandeka, Kitchin Dale, Botha Gordon, Gorman Jason, Garrett Nigel J, Abdool Karim Salim S, Shapiro Lawrence, Williamson Carolyn, Kwong Peter D, Mascola John R, Morris Lynn, Moore Penny L

Abstract excerpt

The elicitation of broadly neutralizing antibodies (bNAbs) is likely to be essential for a preventative HIV-1 vaccine, but this has not yet been achieved by immunization. In contrast, some HIV-1-infected individuals naturally mount bNAb responses during chronic infection, suggesting that years of maturation may be required for neutralization breadth. Recent studies have shown that viral diversification precedes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26457756
DOI: 10.1038/nm.3963
PMCID: PMC4637988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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