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Identification of a broad and potent V3 glycan site bNAb targeting an N332 <sub>gp120</sub> glycan-independent epitope

2025-09-10

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) against HIV-1 can suppress viremia in vivo and inform vaccine development. Here, we characterized 007, a V3 glycan site bNAb exhibiting high levels of antiviral activity against multiclade pseudovirus panels 1–3 (GeoMean IC 50 = 0.012 µg/mL, breadth = 69%, 217 virus strains) by targeting a N332 gp120 glycan-independent V3 epitope, a site of Env vulnerability to which onl...

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Identifiers and source

Literature Corpus work
17e4abfa-2a9d-5bea-a050-87c3421df071
DOI
10.1101/2025.09.05.674437
Open publication

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Identification of a broad and potent V3 glycan site bNAb targeting an N332 <sub>gp120</sub> glycan-independent epitopeDOI 10.1101/2025.09.05.674437
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