Article

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque

2026-01-30

Abstract excerpt

<h4> ABSTRACT </h4> Understanding broadly neutralizing antibody (bnAb) lineage development in rhesus macaques (RMs) infected with Simian-HIV (SHIV) may inform HIV-1 vaccine designs. We analyzed HIV-1 envelope-antibody coevolution in 18 RMs infected by SHIV.BG505 (subtype A) and found highly conserved patterns of antibody recognition and Env escape, including in three animals that developed V3-glycan bnAbs. From...

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Literature Corpus work: 196d8881-57fe-5ce0-89b6-da6023af89b4
DOI: 10.64898/2026.01.29.702664

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