Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.

PLoS genetics - 1 Jan 2015

Ferrari Matteo, Dibitetto Diego, De Gregorio Giuseppe, Eapen Vinay V, Rawal Chetan C, Lazzaro Federico, Tsabar Michael, Marini Federica, Haber James E, Pellicioli Achille

Abstract excerpt

The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 5'-to-3' resection of Double-Strand DNA Breaks (DSBs). Extended 3' single stranded DNA filaments can be exposed from a DSB through the redundant activities of the Exo1 nuclease and the Dna2 nuclease with the Sgs1 helicase. In the absence of Sae2, Mre11 binding to a DSB is prolonged, the two DNA ends cannot be kept tethered, and the DSB is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to DNA End-Joining Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endodeoxyribonucleases

Share to Endonucleases

Share to Exodeoxyribonucleases

Share to Homologous Recombination

Share to Rad52 DNA Repair and Recombination Protein

Share to RecQ Helicases

Source

Open in PubMed Open full text

Identifiers

PMID: 25569305
DOI: 10.1371/journal.pgen.1004928
PMCID: PMC4287487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.PMID 25569305Read ↗

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.Semantic proximity Read ↗

Regulation of DNA Double Strand Breaks Processing: Focus on BarriersSemantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.Semantic proximity Read ↗

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

DNA End Resection: Facts and MechanismsSemantic proximity Read ↗

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.Semantic proximity Read ↗

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.Semantic proximity Read ↗

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signalingSemantic proximity Read ↗

Rad9/53BP1 promotes crossover recombination DNA repair by limiting the Sgs1 and Mph1 helicasesSemantic proximity Read ↗

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.