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Article

Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.

The EMBO journal - 1 Jan 2025

Huang Pei-Ching, Hong Soogil, Alnaser Hasan F, Mimitou Eleni P, Kim Keun P, Murakami Hajime, Keeney Scott

Abstract excerpt

DNA double-strand breaks (DSBs) are nucleolytically processed to generate single-stranded DNA for homologous recombination. In Saccharomyces cerevisiae meiosis, this resection involves nicking by the Mre11-Rad50-Xrs2 complex (MRX), then exonucleolytic digestion by Exo1. Chromatin remodeling at meiotic DSBs is thought necessary for resection, but the remodeling enzyme was unknown. Here we show that the...

Topics

Saccharomyces cerevisiae Proteins
Saccharomyces cerevisiae
Meiosis
Exodeoxyribonucleases
DNA Breaks, Double-Stranded
Chromatin Assembly and Disassembly
Transcription Factors
Nucleosomes
Mutation
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39613969
DOI: 10.1038/s44318-024-00318-8
PMCID: PMC11695836

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Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.PMID 39613969Read ↗

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.Semantic proximity Read ↗

Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions.Semantic proximity Read ↗

Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.Semantic proximity Read ↗

The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosisSemantic proximity Read ↗

DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.Semantic proximity Read ↗

Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.Semantic proximity Read ↗

A Rad50-null mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection and complete loss of germ cells.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.Semantic proximity Read ↗

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.Semantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

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