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Article

Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.

The EMBO journal - 1 Jan 2025

Huang Pei-Ching, Hong Soogil, Alnaser Hasan F, Mimitou Eleni P, Kim Keun P, Murakami Hajime, Keeney Scott

Abstract excerpt

DNA double-strand breaks (DSBs) are nucleolytically processed to generate single-stranded DNA for homologous recombination. In Saccharomyces cerevisiae meiosis, this resection involves nicking by the Mre11-Rad50-Xrs2 complex (MRX), then exonucleolytic digestion by Exo1. Chromatin remodeling at meiotic DSBs is thought necessary for resection, but the remodeling enzyme was unknown. Here we show that the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39613969
DOI: 10.1038/s44318-024-00318-8
PMCID: PMC11695836

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Research trail→

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Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.PMID 39613969Read ↗

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.Semantic proximity Read ↗

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Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.Semantic proximity Read ↗

The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosisSemantic proximity Read ↗

DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.Semantic proximity Read ↗

Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.Semantic proximity Read ↗

A Rad50-null mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection and complete loss of germ cells.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

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