Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.

Cell reports - 13 Jul 2021

Kim BongWoo, Luo Yi, Zhan Xiaoming, Zhang Zilai, Shi Xuanming, Yi Jiaqing, Xuan Zhenyu, Wu Jiang

Abstract excerpt

Neuronal activity-induced enhancers drive gene activation. We demonstrate that BRG1, the core subunit of SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes, regulates neuronal activity-induced enhancers. Upon stimulation, BRG1 is recruited to enhancers in an H3K27Ac-dependent manner. BRG1 regulates enhancer basal activities and inducibility by affecting cohesin binding, enhancer-promoter looping, RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to alpha-Fetoproteins
Share to Anxiety

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Lysine

Share to Phosphoserine

Share to Proto-Oncogene Proteins c-fos

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 34260936
DOI: 10.1016/j.celrep.2021.109357
PMCID: PMC8315893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.PMID 34260936Read ↗

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.Semantic proximity Read ↗

Brg1 modulates enhancer activation in mesoderm lineage commitment.Semantic proximity Read ↗

Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition.Semantic proximity Read ↗

Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and DisordersSemantic proximity Read ↗

Chromatin remodelling enables enhancer resetting to facilitate the ERK transcriptional responseSemantic proximity Read ↗

Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elementsSemantic proximity Read ↗

SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stressSemantic proximity Read ↗

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Semantic proximity Read ↗

SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.Semantic proximity Read ↗

Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation.Semantic proximity Read ↗

Brg1 is required for murine neural stem cell maintenance and gliogenesis.Semantic proximity Read ↗

Loss of Brg1 promotes seizure development via GABAergic system disruptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.