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Article

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.

Nucleic acids research - 1 Jul 2012

Zraly Claudia B, Dingwall Andrew K

Abstract excerpt

Nucleosome remodeling catalyzed by the ATP-dependent SWI/SNF complex is essential for regulated gene expression. Transcriptome profiling studies in flies and mammals identified cell cycle and hormone responsive genes as important targets of remodeling complex activities. Loss of chromatin remodeling function has been linked to developmental abnormalities and aggressive cancers. The Drosophila Brahma (Brm) SWI/SNF...

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Identifiers

PMID: 22467207
DOI: 10.1093/nar/gks288
PMCID: PMC3401471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.PMID 22467207Read ↗

Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function.Semantic proximity Read ↗

SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development.Semantic proximity Read ↗

SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.Semantic proximity Read ↗

The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions.Semantic proximity Read ↗

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Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene ExpressionSemantic proximity Read ↗

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